関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | 7-Amino-1,2,3,4-tetrahydronaphthalen-1-one | HCID 327177 | — |
| 反応物 | 3-(Cyclohexen-1-yl)aniline | HCID 6709749 | — |
| 反応物 | 4-hydroxy-3-methoxy-N-[1-oxo-1,2,3,4-tetrahydronaphthalen-7-yl]phenylacetamide | HCID 22019659 | — |
| 溶媒 | Ethanol hydrochloride | HCID 21887872 | — |
| 生成物 | 4-hydroxy-3-methoxy-N-[1-oxo-2-phenylmethylidene-1,2,3,4-tetrahydronaphthalen-7-yl]phenylacetamide | HCID 69663967 | — |
反応手順
Instead of 3-(cyclohexen-1-yl)aniline (Intermediate 2) in Example 9, 7-amino-1-tetralone is treated in a similar manner to Example 9. The resulting 4-hydroxy-3-methoxy-N-[1-oxo-1,2,3,4-tetrahydronaphthalen-7-yl]phenylacetamide (1 g) is dissolved in 30% hydrogen chloride-ethanol (5 ml), and thereto is added benzaldehyde (433 mg). The mixture is stirred at 25° C. for 18 hours. The precipitated crystals are collected by filtration, and washed with diethyl ether to give the desired compound (700 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07084176B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-18b1747dcc8a42479959da4aec8199c0 |
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| 出典メモ | uspto-grants-2006_08 |
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