Methylhydrazine → (S)-tert-butyl 2-(aminooxy)propanoate
反応式
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][C@@H:13]([CH3:21])[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].CNN>C(Cl)Cl>[NH2:3][O:12][C@@H:13]([CH3:21])[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of (S)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate (73.3 mg, 0.252 mmol) in DCM (Volume: 500 μL) at 0° C. was added methyl hydrazine (13.5 μL, 0.252 mmol). After stirring for 3 h at 0° C., the solids were filtered off and the filtrate was concentrated in vacuo, affording the title compound (assumed quantitative) as a clear oil.
後処理
- filtrationthe solids were filtered off
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-8c5f0762f0e644829567bad5d32795ad
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09174978B2
反応ノート
読み込み中…