化工社化工社 化学情報印刷レポート · 研究参考用
Chloroacetic Acid → 2-(chloromethyl)-4-methoxy-1H-benzo[d]imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetic Acid | HCID 300 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 6-Nitro-o-anisidine | HCID 85491 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(chloromethyl)-4-methoxy-1H-benzo[d]imidazole | HCID 22018753 | 86.6% |
反応手順
A solution of 2-amino-3-methoxy-1-nitrobenzene (0.860 g, 5.11 mmol) in MeOH (50 mL) was hydrogenated (1 atm) over palladium, 10 wt. % on activated carbon (0.163 g). The resultant crude 3-methoxy-1,2-phenylenediamine was reacted with chloroacetic acid (0.953 g, 10.08 mmol) in refluxing 4 N HCl (10 mL) overnight. After aqueous workup, 0.87 g of 2-chloromethyl-4-methoxy-1H-benzimidazole was isolated as a red-brown solid, which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084155B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-24bc86431bd542409b1544b66fd7149e |
| 出典メモ | uspto-grants-2006_08 |