5-[(3-Chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine → 5-[(3-Chloro-5-fluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

反応式

C(SC1C=C(O)C(=O)NC=1)C1C=CC=CC=1.[Cl:17][C:18]1[CH:19]=[C:20]([CH:33]=[C:34]([F:36])[CH:35]=1)[CH2:21][S:22][C:23]1[CH:24]=[C:25]([O:31]C)[C:26]([O:29]C)=[N:27][CH:28]=1>>[Cl:17][C:18]1[CH:19]=[C:20]([CH:33]=[C:34]([F:36])[CH:35]=1)[CH2:21][S:22][C:23]1[CH:24]=[C:25]([OH:31])[C:26](=[O:29])[NH:27][CH:28]=1

参加物

反応物 2

HCID 711862245-[(3-Chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine2 回

HCID 71187166HCID 71187166、化合物

生成物 1

HCID 711872685-[(3-Chloro-5-fluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one

実験手順

Prepared as described for 5-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one (Example 1) from 5-[(3-chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine (Intermediate 13).

後処理

customPrepared

出典と根拠

ORDレコード: ord-938b3249207244a7bf1fae5048b23782
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09180122B2

反応ノート

読み込み中…