化工社化工社 化学情報印刷レポート · 研究参考用
Benzene, 1-bromo-3-nitro- → 2-Bromo-6-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 1-bromo-3-nitro- | HCID 11457 | — |
| 反応物 | O-methylhydroxylammonium chloride | HCID 11639 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 触媒 | Cuprous chloride | HCID 62652 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Bromo-6-nitroaniline | HCID 11469989 | 6% |
反応手順
A mixture of 3-bromonitrobenzene (6.06 g, 30 mmol) and o-methylhydroxylamine hydrochloride (3.13 g, 37.5 mmol) were reacted in the presence of copper (I) chloride (0.59 g, 6 mmol) and potassium t-butoxide (10.1 g, 90 mmol) in DMF (75 mL). Aqueous work-up and chromatography gave 2-amino-3-bromonitrobenzene (0.36 g, 6%) as an orange powder. 1H NMR (CDCl3) δ 6.60 (t, 1H, J=9 Hz), 7.70 (d, 1H, J=9 Hz), 8.14 (d, 1H, J=9 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084155B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-5da6dc30a40e4b98a9086a0a634513ee |
| 出典メモ | uspto-grants-2006_08 |