Hydrochloric Acid → 1258784-67-6

HRID 709410

反応式

HRID 709410 の反応式
[ClH:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C@@H:16]2[CH2:18][C@H:17]2[NH:19]C(=O)OC(C)(C)C)=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([O:9][C:10]1[CH:11]=[CH:12][C:13]([C@@H:16]2[CH2:18][C@H:17]2[NH2:19])=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 15480693tert-Butyl(trans)-2-[4-(benzyloxy)phenyl]cyclopropylcarbamate2 回

生成物 1

HCID 667150851258784-67-6収率 87%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

HCl in Dioxane (390 ml) was added to a solution of tert-butyl ((trans)-2-(4-(benzyloxy)phenyl)cyclopropyl)carbamate (Intermediate U, 78 g, 0.23 mol) in 1,4-dioxane (780 mL) at 0° C. and stirred at RT for 12 h. After completion, the solvent was evaporated and the residue was triturated with diethyl ether (1 L) followed by hexane (1 L) to give (trans)-2-(4-(benzyloxy)phenyl)cyclopropanamine hydrochloride (55 g, 87%) as off-white solid.

後処理

  1. customAfter completion, the solvent was evaporated
  2. customthe residue was triturated with diethyl ether (1 L)

出典と根拠

ORDレコード
ord-3a5fe46482114071b07b88612e421bc5
出典データセット
uspto-grants-2015_11
特許番号
US09181198B2

関連ノート

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