Cesium carbonate → 2-(4-Carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester

HRID 709486

反応式

HRID 709486 の反応式
[Cl:1][C:2]([Cl:26])([Cl:25])[CH2:3][O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][S:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](CC(O)=O)[CH:15]=1.SC1C=CC([CH2:34][C:35]([OH:37])=[O:36])=CC=1.ClC(Cl)(Cl)COC(=O)C1C=CC=CC=1CBr.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[Cl:26][C:2]([Cl:1])([Cl:25])[CH2:3][O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][S:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:34][C:35]([OH:37])=[O:36])=[CH:18][CH:19]=1

参加物

6

反応物 4

HCID 10796Cesium carbonateHCID 33905114-Mercaptophenylacetic acidHCID 668648212-(3-Carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl esterHCID 668652492-Bromomethyl-benzoic acid 2,2,2-trichloro-ethyl ester

生成物 1

HCID 668648682-(4-Carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The titled compound was prepared according to the method described for 2-(3-carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester above from 4-mercapto-phenylacetic acid (0.73 g, 4.33 mmol), 2-bromomethyl-benzoic acid 2,2,2-trichloro-ethyl ester (1.50 g, 4.33 mmol), cesium carbonate (1.69 g, 5.20 mmol) and DMF (25 mL). The crude material (1.88 g, 100%) was used for the next step without further purification; Mass spectrum: M−H+ 432.

後処理

  1. customThe crude material (1.88 g, 100%) was used for the next step without further purification

出典と根拠

ORDレコード
ord-4f1698b5de5d47e3a6e060f6f36c6888
出典データセット
uspto-grants-2015_11
特許番号
US09181181B2

関連ノート

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