Water → (3-Methoxy-5-methylphenyl)methanol

HRID 709721ノート

反応式

HRID 709721 の反応式
Br[CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[CH:4]=1.C(=O)([O-])[OH:13].[Na+].O>CC(C)=O>[CH3:11][O:10][C:5]1[CH:4]=[C:3]([CH2:2][OH:13])[CH:8]=[C:7]([CH3:9])[CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 5855341-(Bromomethyl)-3-methoxy-5-methylbenzene

生成物 1

HCID 11030016(3-Methoxy-5-methylphenyl)methanol収率 80.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 1-(bromomethyl)-3-methoxy-5-methylbenzene (2.14 g) in acetone (80 mL) were added sodium hydrogen carbonate (1.05 g) and water (50 mL), and the mixture was heated under reflux for 18 hr. The reaction mixture was extracted with ethyl acetate, and the extract was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.22 g) as a yellow oil.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 18 hr
  3. extractionThe reaction mixture was extracted with ethyl acetate
  4. washthe extract was washed with saturated brine
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-cb45ff73b9a34a3c921d4b4483304c8b
出典データセット
uspto-grants-2015_11
特許番号
US09181186B2

反応ノート

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