Potassium Carbonate → 3-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-4-(4-o-tolyl-piperazin-1-yl)-benzamide

HRID 710020ノート

反応式

HRID 710020 の反応式
F[C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][C:13]2=[O:17])=[O:7])=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].C([O-])([O-])=O.[K+].[K+].[C:29]1([CH3:41])[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>CN(C=O)C>[N+:20]([C:3]1[CH:4]=[C:5]([CH:18]=[CH:19][C:2]=1[N:38]1[CH2:39][CH2:40][N:35]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[CH3:41])[CH2:36][CH2:37]1)[C:6]([NH:8][CH2:9][CH2:10][CH2:11][N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17])=[O:7])([O-:22])=[O:21]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 919652-MeppHCID 712246724-fluoro-3-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-benzamide

生成物 1

HCID 712248173-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-4-(4-o-tolyl-piperazin-1-yl)-benzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

To a solution of 4-Fluoro-3-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-benzamide (2.0 g, 6.47 mmol) in DMF (10 mL), K2CO3 (1.7 g, 12.94 mmol) was added followed by 1-o-tolyl-piperazine (1.7 g, 9.7 mmol), and the reaction mixture was stirred at room temperature for 16 h. DMF (2.0 mL) was added and filtered. The solid was washed with MeOH (300 mL) and methanol layer was evaporated to give the acid 3-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-4-(4-o-tolyl-piperazin-1-yl)-benzamide in the first crop (1.8 g, 62%).

後処理

  1. filtrationfiltered
  2. washThe solid was washed with MeOH (300 mL) and methanol layer
  3. customwas evaporated

出典と根拠

ORDレコード
ord-5685e88cfe8b44a7a0a7238c32cc46e6
出典データセット
uspto-grants-2015_11
特許番号
US09181226B2

反応ノート

読み込み中…