化工社化工社 化学情報印刷レポート · 研究参考用
N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide → Isopropyl 4-{5-[6-(methylcarbamoyl)pyridin-3-yl]benzo[d]oxazol-2-yl}piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide | HCID 44119560 | — |
| 反応物 | Isopropyl 4-(5-bromobenzo[d]oxazol-2-yl)piperidine-1-carboxylate | HCID 71257568 | — |
| 生成物 | Isopropyl 4-{5-[6-(methylcarbamoyl)pyridin-3-yl]benzo[d]oxazol-2-yl}piperidine-1-carboxylate | HCID 71257260 | 5.8% |
反応手順
Following the General Procedure-1, the titled compound (20 mg) was prepared from Intermediate 13 (300 mg, 0.82 mmol) and N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide (256 mg, 0.98 mmol) as a brown solid. M.P.: 158-161° C. MS (m/z): 423.5 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181214B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-ac475505ca714dffa884cb922dd6c260 |
| 出典メモ | uspto-grants-2015_11 |