反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]#[C:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][CH:19]=[CH:18]3)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].C(C1C=C2C(=CC=1)NC=C2)#CCCCCCC>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10])[CH2:13][CH2:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][CH:19]=[CH:18]2参加物
3
実験手順
When the product of Step A was substituted for 5-(oct-1-ynyl)-1H-indole in Example 3, Step B, the identical process afforded the title compound in 86% yield., as a colourless syrup. 1H-NMR (CDCl3) 2.79-3.03 (m, 4H); 3.8 (s, 3H); 3.82 (s, 6H); 6.4 (s, 2H); 6.47 (m, 1H); 7.03 (dd, 1H, J=1.3; 8.3 Hz); 7.18 (m, 1H); 7.31 (d, 1H, J=8.3 Hz); 7.45 (s, 1H); 8.09 (broad s, 1H);
出典と根拠
- ORDレコード
- ord-1b600927d162484385e043a8701e45cb
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181182B2
関連ノート
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