5-Iodo-2-tritylisoindoline → tert-Butyl 2,2-dimethyl-5-((6-(oct-1-ynyl)-3,4-dihydroquinolin-1(2H)-yl)methyl)-1,3-dioxan-5-ylcarbamate

関与物質

反応手順

When the product of Step B is substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the identical process afforded the title compound in 35% yield, as a brownish foam. 1H-NMR (CDCl3) 0.88 (m, 3H); 1.41 (m, 8H); 1.50 (m, 2H); 1.87 (m, 2H); 2.34 (tr, 2H, J=7.0 Hz); 2.72 (tr, 2H, J=6.3 Hz); 3.26-3.32 (m, 2H); 3.69 (5, 2H); 3.9 (s, 3H); 4.65 (s, 1H); 6.68 (d, 1H, J=8.7 Hz); 6.98 (s, 1H); 7.04 (d, 1H, J=8.7 Hz).

情報源と証拠