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p-Diiodobenzene → tert-Butyl 5-((4-iodophenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Diiodobenzene | HCID 12208 | — |
| 反応物 | 1-Octyne | HCID 12370 | — |
| 反応物 | 1,1-Dimethylethyl N-(5-ethynyl-2,2-dimethyl-1,3-dioxan-5-yl)carbamate | HCID 11514385 | — |
| 反応物 | 5-Iodo-2-tritylisoindoline | HCID 66726248 | — |
| 生成物 | tert-Butyl 5-((4-iodophenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate | HCID 66726604 | 34% |
反応手順
When tert-butyl-5-ethynyl-2,2-dimethyl-1,3-dioxan-5-yl-carbamate was substituted for 1-octyne and 1,4 diiodobenzene was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 34% yield, as the pale solid. 1H-NMR (CDCl3) 1.43 (s, 3H); 1.46 (s, 9H); 1.48 (s, 3H); 2.40 (s, 1H); 3.99 (d, 2H, J=11.34 Hz); 4.00 (d, 2H, J=11.37 Hz); 5.18 (broad s, 1H); 7.12 (d, 2H, J=8.28 Hz); 7.61 (d, 2H, J=8.28 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181182B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-2ac38624b5b84d1db10a645c9ce73a18 |
| 出典メモ | uspto-grants-2015_11 |