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6-Iodo-1H-indole → tert-Butyl 5-((3-(1-admantyl)-4-(octyloxy)phenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Iodo-1H-indole | HCID 10999215 | — |
| 反応物 | 1,1-Dimethylethyl N-(5-ethynyl-2,2-dimethyl-1,3-dioxan-5-yl)carbamate | HCID 11514385 | — |
| 反応物 | 2-(1-Admantyl)-4-iodo-1-(octyloxy)benzene | HCID 66726400 | — |
| 反応物 | 4'-Ethynyl-2-(trifluoromethyl)biphenyl | HCID 86661806 | — |
| 生成物 | tert-Butyl 5-((3-(1-admantyl)-4-(octyloxy)phenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate | HCID 66726408 | — |
反応手順
When the product of Step A was substituted for 6-iodoindole and tert-butyl 5-ethynyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 4′-ethynyl-2-(trifluoromethyl) biphenyl in Example 59, Step B the identical process afforded the title compound in 48%, as creamy paste. 1H-NMR (CDCl3) 0.85 (tr, 3H, J=8.99 Hz); 1.27-1.47 (m, 23H); 1.73 (s, 6H); 1.8-1.87 (m, 2H); 2.06 (s, 9H); 3.94 (tr, 2H, J=6.34 Hz); 3.99 (d, 2H, J=11.44 Hz); 4.08 (d, 2H, J=11.52 Hz); 5.17 (s, 1H); 6.73 (d, 1H, J=8.41 Hz); 7.19-7.21 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181182B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-992fdb5e2234458abd832c98c6abadb8 |
| 出典メモ | uspto-grants-2015_11 |