反応式
[C:1]12([C:11]3[CH:16]=[C:15](I)[CH:14]=[CH:13][C:12]=3[O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.IC1C=C2C(C=CN2)=CC=1.[C:37]([C:39]1([NH:47][C:48](=[O:54])[O:49][C:50]([CH3:53])([CH3:52])[CH3:51])[CH2:44][O:43][C:42]([CH3:46])([CH3:45])[O:41][CH2:40]1)#[CH:38].C(C1C=CC(C2C=CC=CC=2C(F)(F)F)=CC=1)#C>>[C:1]12([C:11]3[CH:16]=[C:15]([C:38]#[C:37][C:39]4([NH:47][C:48](=[O:54])[O:49][C:50]([CH3:53])([CH3:52])[CH3:51])[CH2:44][O:43][C:42]([CH3:46])([CH3:45])[O:41][CH2:40]4)[CH:14]=[CH:13][C:12]=3[O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2参加物
5
反応物 4
生成物 1
実験手順
When the product of Step A was substituted for 6-iodoindole and tert-butyl 5-ethynyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 4′-ethynyl-2-(trifluoromethyl) biphenyl in Example 59, Step B the identical process afforded the title compound in 48%, as creamy paste. 1H-NMR (CDCl3) 0.85 (tr, 3H, J=8.99 Hz); 1.27-1.47 (m, 23H); 1.73 (s, 6H); 1.8-1.87 (m, 2H); 2.06 (s, 9H); 3.94 (tr, 2H, J=6.34 Hz); 3.99 (d, 2H, J=11.44 Hz); 4.08 (d, 2H, J=11.52 Hz); 5.17 (s, 1H); 6.73 (d, 1H, J=8.41 Hz); 7.19-7.21 (m, 2H).
出典と根拠
- ORDレコード
- ord-992fdb5e2234458abd832c98c6abadb8
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181182B2
関連ノート
読み込み中…