6-Iodopyridine-3-carboxylic acid → 6-(Prop-1-yn-1-yl)nicotinic acid
反応式
I[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.I[C:12]1[CH:13]=C(C=C[C:20]=1CCC)C(O)=O>>[C:20]([C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)#[C:12][CH3:13]参加物
3
実験手順
When 6-iodonicotinic acid was substituted for the 3-iodo-4-propylbenzoic acid in Example 47, Step B, the similar process afforded the title compound in 45% yield, as yellow solid. 1H-NMR (CDCl3) 2.12 (s, 3H); 7.25 (broad s, 1H+H2O); 7.46 (dd, 1H, J=0.6, 7.6 Hz); 8.2 (dd, 1H, J=2.16, 6 Hz); 9.23 (dd, 1H, J=0.8, 1.4 Hz).
出典と根拠
- ORDレコード
- ord-2abe0e9771bf47f3b6e4f093ccec56c1
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181182B2
反応ノート
読み込み中…