5-(Oct-1-ynyl)-1H-indole → 2,2,2-Trifluoro-1-(7-octyl-1,2,4,5-tetrahydrobenzo[d]azepin-3-yl)ethanone

HRID 710489

反応式

HRID 710489 の反応式
[F:1][C:2]([F:25])([F:24])[C:3]([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[C:13]([C:16]#[C:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:14]=[CH:15][C:8]=2[CH2:7][CH2:6]1)=[O:4].C(C1C=C2C(=CC=1)NC=C2)#CCCCCCC>>[F:25][C:2]([F:1])([F:24])[C:3]([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:14]=[CH:15][C:8]=2[CH2:7][CH2:6]1)=[O:4]

参加物

3

反応物 2

HCID 667267515-(Oct-1-ynyl)-1H-indoleHCID 866618182,2,2-Trifluoro-1-(7-(oct-1-ynyl)-1,2,4,5-tetrahydrobenzo-[d]azepin-3-yl)ethanone

生成物 1

HCID 866618192,2,2-Trifluoro-1-(7-octyl-1,2,4,5-tetrahydrobenzo[d]azepin-3-yl)ethanone

実験手順

When the product of Step C was substituted for 5-(oct-1-ynyl)-1H-indole in Example 3, Step B, the similar process afforded the title compound in 90%, as pale oil. 1H-NMR (CDCl3) 0.87 (tr, 3H, J=6.96 Hz), 1.25-1.28 (m, 10H); 1.4-1.46 (m, 2H); 2.50-2.56 (m, 2H); 2.90-2.95 (m, 4H); 3.64-3.66 (m, 2H); 3.73-3.75 (m, 2H); 6.81-7.07 (m, 3H).

出典と根拠

ORDレコード
ord-c2977f2089ea4b48ac0f7e9aea286bf1
出典データセット
uspto-grants-2015_11
特許番号
US09181182B2

関連ノート

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