Phenylacetyl chloride → HCID 178420211、化合物

関与物質

反応手順

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg, 1 mmol), TEA (0.153 ml; 1.1 mmol), phenylacetylchloride (170 mg, 0.145 ml, 1.1 mmol) and POCl3 (0.5 ml; 5.5 mmol) as described in method 1; yield: 0.026 mg (9.4%); MS m/z: 277.4 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 4.34 (s, 2H); 7.25-7.28 (m, 1H); 7.29-7.38 (m, 4H); 7.83 (d, 1H, 3J=8.7 Hz); 7.91 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.19-8.20 (m, 1H); 8.85 (s, 1H); HPLC (METHOD [A]): rt 11.17 min (100%)

情報源と証拠