Phosphorus oxychloride → HCID 178420223、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Phosphorus oxychloride	HCID 24813	—
反応物	Benzenepropanoyl chloride	HCID 64801	—
反応物	1H-benzimidazole-5-carbohydrazide	HCID 16637119	—
生成物	HCID 178420223	HCID 178420223	—

反応手順

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg, 1 mmol), TEA (0.153 ml; 1.1 mmol), phenylpropionylchloride (185 mg, 0.163 ml, 1.1 mmol) and POCl3 (0.5 ml; 5.5 mmol) as described in method 1; yield: 0.031 mg (10.7%); MS m/z: 291.3 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.09 (t, 2H, 3J=7.7 Hz); 3.25 (t, 2H, 3J=7.5 Hz); 7.15-7.19 (m, 1H); 7.23-7.27 (m, 4H); 7.84 (d, 1H, 3J=8.7 Hz); 7.92 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.20 (br s, 1H); 8.87 (s, 1H); HPLC (METHOD [A]): rt 11.82 min (100%)

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09181233B2
出典データセット	uspto-grants-2015_11
ORD ID	ord-f289b40c92594a98b6a03341f88125ce
出典メモ	uspto-grants-2015_11