関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Bromoselenobenzene | HCID 123446 | — |
| 反応物 | 7-(Ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one | HCID 67378368 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Bromo-7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one | HCID 67378359 | — |
反応手順
To a solution of 7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one (20 mg, 0.1 mmol) and pyridine (27 μL, 0.3 mmol) in DCM (2 mL) was added phenylselenium bromide (72 mg, 0.3 mmol). The mixture was heated at 39° C. for 6 h, and then the solvent was removed under vacuum. The residue was chromatographed on silica gel (30% ethyl acetate in hexanes eluant) to provide the title compound. MS (m/z) 282.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09181238B2 |
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| 出典データセット | uspto-grants-2015_11 |
|---|
| ORD ID | ord-812fa3d5a0cb45b989bb734a57ddfeb3 |
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| 出典メモ | uspto-grants-2015_11 |
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