Hydrochloric Acid → HCID 178497304、化合物

HRID 711087ノート

反応式

HRID 711087 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][NH:3]1.Cl.[CH3:15]O>>[OH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:15])=[O:12])=[CH:8][CH:9]=2)[NH:4][N:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 533377172,3-Dihydro-3-oxo-1H-indazole-6-carboxylic acid

生成物 1

HCID 178497304HCID 178497304、化合物収率 100%

実験手順

3-Oxo-2,3-dihydro-1H-indazole-6-carboxylic acid (1.5 g, 8.4 mmol) was suspended in methanol (17 mL). Concentrated hydrochloric acid (3.1 mL, 101 mmol) was added and the reaction was heated to reflux for 24 hours. The reaction was concentrated to give the title compound (1.6 g, 100%). +ESI (M+H) 193.1; 1H NMR (400 MHz, DMSO-d6, δ): 11.98 (br. s., 1H), 7.89 (s, 1H), 7.72 (d, J=8.6 Hz, 1H), 7.50 (dd, J=8.5, 1.3 Hz, 1H), 3.85 (s, 3H).

後処理

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 24 hours
  3. concentrationThe reaction was concentrated

出典と根拠

ORDレコード
ord-ff20ba9906f44c66b1331711b9a4ab7b
出典データセット
uspto-grants-2015_11
特許番号
US09181252B2

反応ノート

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