Triethylamine → HCID 28787470、化合物

HRID 711218ノート

反応式

HRID 711218 の反応式
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=1.C(N(CC)CC)C>C(O)CCC>[S:4]1[CH2:5][CH2:6][N:1]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=2)[CH2:2][CH2:3]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 67164ThiomorpholineHCID 51520946-Chloro-3-pyridinecarbonitrile

生成物 1

HCID 28787470HCID 28787470、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

反応条件

温度
100 °C

実験手順

To a round bottom flask was added thiomorpholine 8-1 (3.6 g, 34.8 mmol), 6-chloronicotinonitrile 8-2 (4.0 g, 29 mmol), triethylamine (8 mL, 58 mmol) and butanol (10 mL). The reaction was stirred at 100° C. for 1 hour. After cooling to room temperature, the reaction formed a solid cake. The cake was triturated in 50 mL H2O at 100° C. After cooling, the solid was collected by filtration to give 6-thiomorpholinonicotinonitrile 8-3 as an off-white solid. MS m/z 206.1 (M+1).

後処理

  1. temperatureAfter cooling to room temperature
  2. customthe reaction formed a solid cake
  3. customThe cake was triturated in 50 mL H2O at 100° C
  4. temperatureAfter cooling
  5. filtrationthe solid was collected by filtration

出典と根拠

ORDレコード
ord-be08e873d5954a018ab901a065b4c549
出典データセット
uspto-grants-2015_11
特許番号
US09181235B2

反応ノート

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