Acetic Acid → 8-Bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 711383ノート

反応式

HRID 711383 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([NH:12][NH2:13])=[N:9]2)=[CH:4][CH:3]=1.[CH3:14][C:15](O)=O>O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]3[N:9]2[C:14]([CH3:15])=[N:13][N:12]=3)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 176Acetic AcidHCID 52002657-Bromo-2-hydrazinylquinoxaline

生成物 1

HCID 668035548-Bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline収率 91%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 7-bromo-2-hydrazinylquinoxaline (200 mg, 0.84 mmol) and AcOH (5 mL) was refluxed overnight. After cooling to r.t., the mixture was treated with water (10 mL); the solid was collected on a filter and dried by vacuum to give 8-bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline as gray solid (200 mg, yield: 91.0%).

後処理

  1. temperaturewas refluxed overnight
  2. customthe solid was collected on
  3. filtrationa filter
  4. customdried by vacuum

出典と根拠

ORDレコード
ord-992eb34c765e4fa783bacf5e677d8d00
出典データセット
uspto-grants-2015_11
特許番号
US09181264B2

反応ノート

読み込み中…