Formic Acid → N-(6-bromo-2-methoxypyridin-3-yl)formamide

HRID 71178ノート

反応式

HRID 71178 の反応式
[CH:1]([OH:3])=O.C(OC(=O)C)(=O)C.[Br:11][C:12]1[N:17]=[C:16]([O:18][CH3:19])[C:15]([NH2:20])=[CH:14][CH:13]=1>CCCCCC>[Br:11][C:12]1[N:17]=[C:16]([O:18][CH3:19])[C:15]([NH:20][CH:1]=[O:3])=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 105361376-Bromo-2-methoxypyridin-3-amine

生成物 1

HCID 71492501N-(6-bromo-2-methoxypyridin-3-yl)formamide

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

反応条件

温度
0 °C

実験手順

To formic acid (12 mL) was added acetic anhydride (12 mL) at 0° C., and the mixture was stirred at 0° C. for 30 min. 6-Bromo-2-methoxypyridin-3-amine (8.8 g) was gradually added to the reaction mixture at 0° C. over 10 min, and the mixture was stirred at 0° C. for 30 min. IPE (50 mL) and hexane (50 mL) were added to the reaction mixture, and the mixture was stirred at room temperature for 30 min. The obtained solid was collected by filtration to give the title compound (8.1 g).

後処理

  1. stirringthe mixture was stirred at 0° C. for 30 min
  2. stirringthe mixture was stirred at room temperature for 30 min
  3. filtrationThe obtained solid was collected by filtration

出典と根拠

ORDレコード
ord-fbf033e887504119a6ae793a850510ce
出典データセット
uspto-grants-2014_09
特許番号
US08822699B2

反応ノート

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