HCID 12715772、化合物 → 2-Amino-6-(ethylamino)benzonitrile
反応式
[CH2:1]([NH:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[C:5]=1[C:6]#[N:7])[CH3:2]>C(O)C(F)(F)F.FC(F)(F)C(O)C(F)(F)F>[NH2:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:4]([NH:3][CH2:1][CH3:2])[C:5]=1[C:6]#[N:7]参加物
3
実験手順
Prepared as in Example 254b from 2-(ethylamino)-6-nitrobenzonitrile (Example 259c) using Trifluoroethanol/Hexafluoroisopropanol (2:1) as solvent, in 81% yield. 1H NMR (400 MHz, DMSO-d6) δ 1.14 (t, J=7.2 Hz, 3H), 3.15-3.22 (m, 2H), 5.41 (bt, J=5.2 Hz, NH), 5.64 (s, NH2), 5.82 (d, J=8.0 Hz, 1H), 5.96 (d, J=8.0 Hz, 1H), 7.00 (t, J=8.4 Hz, 1H). MS 162 (MH+).
出典と根拠
- ORDレコード
- ord-8ac7aeea63bb455dbd6c8ecb7671436f
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181276B2
反応ノート
読み込み中…