Sulfuric Acid → Methyl 4-fluoro-3-methoxybenzoate

HRID 71193

反応式

HRID 71193 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12].S(=O)(=O)(O)O.[C:18](=O)([O-])O.[Na+]>CO>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:18])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 5984364-Fluoro-3-methoxybenzoic acid

生成物 1

HCID 592847Methyl 4-fluoro-3-methoxybenzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-fluoro-3-methoxybenzoic acid (2.33 g) and sulfuric acid (0.2 mL) in methanol (20 mL) was heated under reflux for 10 hr, and allowed to cool to room temperature. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, the solvent was evaporated under reduced pressure, and water was added to the residue. The resultant precipitate was collected by filtration to give the title compound (2.31 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 10 hr
  3. customthe solvent was evaporated under reduced pressure, and water
  4. additionwas added to the residue
  5. filtrationThe resultant precipitate was collected by filtration

出典と根拠

ORDレコード
ord-e0698cf517924db49b93a7991e44b852
出典データセット
uspto-grants-2014_09
特許番号
US08822699B2

関連ノート

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