1-tert-Butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylate → Ethyl 4-methylpiperidine-4-carboxylate hydrochloride
反応式
[CH3:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:20].O1CCOCC1>O1CCOCC1>[ClH:20].[CH3:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1参加物
4
実験手順
To an ice-cold solution of O1-tert-butyl O4-ethyl 4-methylpiperidine-1,4-dicarboxylate (1 g, 3.68 mmol) in 1,4-dioxane (10 mL) was added HCl-1,4-dioxane (4.0 M, 15 mL) solution. The mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain brown solid material (0.90 g) that was carried forward to the next step without purification. MS: 172.16 [M+H]+.
後処理
- customAfter completion of reaction (by TLC), solvent
- customwas evaporated
出典と根拠
- ORDレコード
- ord-299fe4dfdfa74898a0516eeaf7e186e2
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181234B2
反応ノート
読み込み中…