Ethylamine → (2,3,5-Tribromo-4-methoxy-phenyl)thiourea

HRID 712189ノート

反応式

HRID 712189 の反応式
[Br:1][C:2]1[C:7]([Br:8])=[C:6]([O:9][CH3:10])[C:5]([Br:11])=[CH:4][C:3]=1[NH:12][C:13]([NH:15]C(=O)OCC)=[S:14].C(N)C>>[Br:1][C:2]1[C:7]([Br:8])=[C:6]([O:9][CH3:10])[C:5]([Br:11])=[CH:4][C:3]=1[NH:12][C:13]([NH2:15])=[S:14]

参加物

3

反応物 2

HCID 6341EthylamineHCID 86663965Ethyl N-[(2,3,5-tribromo-4-methoxy-phenyl)carbamothioyl]carbamate

生成物 1

HCID 86663966(2,3,5-Tribromo-4-methoxy-phenyl)thiourea

実験手順

Ethyl N-[(2,3,5-tribromo-4-methoxy-phenyl)carbamothioyl]carbamate (500 mg, 1.02 mmol) was dissolved in ethylamine solution (5.09 mL, 10.18 mmol, 2 M in THF) and stirred at rt overnight. The mixture was concentrated to dryness under reduced pressure to give the desired compound as an off white solid. The mixture was used with no further purification in the next step. m/z: 416.83/418.84/420.83/422.83 [M+H]+.

後処理

  1. concentrationThe mixture was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-c09e4979c7b846c69b5eff87f87c6178
出典データセット
uspto-grants-2015_11
特許番号
US09181234B2

反応ノート

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