化工社化工社 化学情報印刷レポート · 研究参考用
1,4-Dioxane hydrochloride → Ethyl 4-cyanopiperidine-4-carboxylate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 反応物 | 1-tert-Butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate | HCID 57750376 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Ethyl 4-cyanopiperidine-4-carboxylate hydrochloride | HCID 14294360 | — |
反応手順
To an ice-cold solution of O1-tert-butyl O4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (0.4 g, 1.41 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4 M, 5 mL) solution. The resulting mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain the product as a solid (0.28 g). MS: 183.27 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181234B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-34de48a7e7044ab0bc5ba72bcaffcbd0 |
| 出典メモ | uspto-grants-2015_11 |