1,4-Dioxane hydrochloride → Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride

HRID 712220ノート

反応式

HRID 712220 の反応式
[F:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:20].O1CCOCC1>O1CCOCC1>[ClH:20].[F:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21306965Ethyl N-Boc-4-fluoropiperidine-4-carboxylate

生成物 1

HCID 24729616Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To an ice-cold solution of 1-tert-butyl 4-ethyl 4-fluoropiperidine-1,4-dicarboxylate (1.0 g, 3.89 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4.0 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (By TLC), solvent was evaporated to obtain brownish solid material (0.78 g) that was carried forward to the next step without purification. MS: 176.20 [M+H]+.

後処理

  1. customAfter completion of reaction (By TLC), solvent
  2. customwas evaporated

出典と根拠

ORDレコード
ord-66adb15eb9754d9baab078a1ad65a9f1
出典データセット
uspto-grants-2015_11
特許番号
US09181234B2

反応ノート

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