1-tert-Butyl 4-ethyl 4-(prop-2-en-1-yl)piperidine-1,4-dicarboxylate → Ethyl 4-allyl-4-piperidinecarboxylate hydrochloride
反応式
[CH2:1]([C:4]1([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[ClH:22].O1CCOCC1>O1CCOCC1>[ClH:22].[CH2:1]([C:4]1([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)[CH:2]=[CH2:3]参加物
4
実験手順
To an ice-cold solution of 1-tert-butyl 4-ethyl 4-allylpiperidine-1,4-dicarboxylate (2 g, 6.70 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4.0 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (by TLC), the solvent was evaporated to obtain a brownish solid material (1.30 g) that was carried forward to the next step without further purification. MS: 198.28 [M+H]+.
後処理
- customAfter completion of reaction (by TLC)
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-e9c9489505994ca786e2309e80d29c5c
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181234B2
反応ノート
読み込み中…