Hydrochloric Acid → Ethyl 4-hydroxypiperidine-4-carboxylate

反応式

[OH:1][C:2]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.[CH3:12][CH2:13]O>>[OH:1][C:2]1([C:8]([O:10][CH2:12][CH3:13])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 44371984-hydroxypiperidine-4-carboxylic Acid

生成物 1

HCID 22717992Ethyl 4-hydroxypiperidine-4-carboxylate

反応条件

温度: 80 °C

実験手順

To a solution of 4-hydroxypiperidine-4-carboxylic acid (1.20 g, 8.26 mmol) in EtOH (30 ml) was added conc. HCl (5 ml) at rt and the mixture heated up to 80° C. for 2-3 h. After completion (by TLC), solvent was evaporated under reduced pressure to obtain the desired product (1.20 g, crude) which was carried forward for next step without further purification. 1H NMR (D2O): δ 4.20 (q, J=7.20 Hz, 2H), 3.28 (M, 4H), 2.22 (m, 2H), 1.91 (m, 2H), and 1.22 (t, J=7.20 Hz, 3H).

後処理

customAfter completion (by TLC), solvent was evaporated under reduced pressure

出典と根拠

ORDレコード: ord-be55e4bfe4414e40959400e0b8e12611
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09181234B2

反応ノート

読み込み中…