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Benzimidazole → Ethyl-3-(benzimidazol-1-yl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzimidazole | HCID 5798 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 3-bromopropionate | HCID 68320 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl-3-(benzimidazol-1-yl)propanoate | HCID 15878098 | 91% |
反応手順
Ethyl-3-bromopropanoate (1.29 g, 7.1 mmol), benzimidazole (0.70 g, 5.9 mmol), and potassium carbonate (2.44 g, 17.7 mmol) were combined in anhydrous acetonitrile (60 mL) and heated to reflux for 3 days. Aqueous work-up gave ethyl-3-(benzimidazol-1-yl)propanoate (1.17 g, 91%). 1H NMR (CDCl3) δ 2.02 (s, 3H), 2.26 (m, 2H), 4.10 (t, 2H, J=6 Hz), 4.30 (t, 2H, J=6 Hz), 7.28 (br, 2H), 7.33 (br, 1H), 7.84 (br, 1H), 7.94 (br, 1H), 7.60 (br, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084155B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-2168bdfd01ef43e599b82ce28d951c97 |
| 出典メモ | uspto-grants-2006_08 |