Hydrochloric Acid → HCID 86672457、化合物
反応式
[F:1][CH:2]([F:29])[CH2:3][N:4]1[CH2:9][C:8]2([CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[O:7][CH:6]([C:22]2[O:23][C:24]([CH2:27][CH3:28])=[CH:25][N:26]=2)[CH2:5]1.[ClH:30]>C(Cl)Cl>[ClH:30].[F:29][CH:2]([F:1])[CH2:3][N:4]1[CH2:9][C:8]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[O:7][CH:6]([C:22]2[O:23][C:24]([CH2:27][CH3:28])=[CH:25][N:26]=2)[CH2:5]1参加物
4
実験手順
To a solution of tert-butyl 4-(2,2-difluoroethyl)-2-(5-ethyloxazol-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (154 mg, 0.37 mmol) in DCM (0.4 mL) was added HCl (464 μL of 4 M solution in dioxane, 1.85 mmol) and the reaction mixture was stirred at room temperature for 1 hour. The solvent and excess HCl were removed under reduced pressure and the residue was triturated with Et2O to yield 4-(2,2-difluoroethyl)-2-(5-ethyloxazol-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecane hydrochloride salt (138 mg, 96%) as a white solid. ESI-MS m/z calc. 315.2. found 316.3 (M+1)+; Retention time: 1.07 minutes (3 min run).