Hydrochloric Acid → Hydrochloric Acid

HRID 713178ノート

反応式

HRID 713178 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([CH:22]=1)[C:7]([CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)=[O:8].[ClH:24]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([C:7]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[O:8])[CH:22]=1.[ClH:24]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 49761188tert-Butyl 4-(5-chloro-2-fluorobenzoyl)piperidine-1-carboxylate

生成物 2

HCID 313Hydrochloric Acid収率 475%HCID 49761187(5-Chloro-2-fluorophenyl)(piperidin-4-yl)methanone

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of tert-butyl 4-(5-chloro-2-fluorobenzoyl)piperidine-1-carboxylate (287.9 mg, 0.843 mmol) in dioxane (2.41 mL) was treated with HCl (2.11 mL, 8.43 mmol) at rt and the resulting reaction mixture was stirred overnight. The reaction mixture was diluted with hexanes and filtered by suction to afford (5-chloro-2-fluorophenyl)(piperidin-4-yl)methanone as its HCl salt (146 mg, 62.3%) as a yellow solid. ESI-MS m/z [M+H]+242.20.

後処理

  1. customthe resulting reaction mixture
  2. filtrationfiltered by suction

出典と根拠

ORDレコード
ord-9d49f41d15444870bf1ce1c65a16e3fa
出典データセット
uspto-grants-2015_11
特許番号
US09181249B2

反応ノート

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