Hydrochloric Acid → HCID 71212150、化合物

HRID 713404ノート

反応式

HRID 713404 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:19](=[CH:20][CH:21]=1)[C:18](=[O:22])[C:7]1([CH2:12][CH2:11][N:10](C(OCC)=O)[CH2:9][CH2:8]1)[CH2:6]2.Cl>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:19](=[CH:20][CH:21]=1)[C:18](=[O:22])[C:7]1([CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH2:6]2

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 71227303Ethyl 5-methoxy-1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate

生成物 1

HCID 71212150HCID 71212150、化合物収率 113.3%

実験手順

A stirred solution of ethyl 5-methoxy-1-oxo-1,3-dihydrospiro[indene-2,4′-piperidine]-1′-carboxylate (590 mg, 1.95 mmol) in HCl (6.5 mL, 38.9 mmol) was heated at 100° C. overnight. The reaction mixture was concentrated to dryness to give the title compound (511 mg, 2.21 mmol) without any additional purification. MS calculated for C14H17NO2 232.3. found (ESI) m/z 232.4 (M+H)+, retention time 0.90 min.

後処理

  1. concentrationThe reaction mixture was concentrated to dryness

出典と根拠

ORDレコード
ord-7b0f27ccf4d9498eba425aa0118954a5
出典データセット
uspto-grants-2015_11
特許番号
US09181266B2

反応ノート

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