化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 1-[(Pyridin-2-yl)methyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl 4-(pyridin-2-ylmethyl)piperazine-1-carboxylate | HCID 10062065 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-[(Pyridin-2-yl)methyl]piperazine | HCID 808714 | — |
反応手順
A solution of 0.11 g (0.4 mmol) of the title compound from Step A above in 1 mL dichloromethane and 1 mL trifluoroacetic acid was stirred at ambient temperature for 1 h. All volatiles were removed in vacuo and the crude light brown residue was carried forward without purification. LC/MS: m/z (ES) 178.2 (MH)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09186354B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-6a88eeb56878449f970f1eca834df1c4 |
| 出典メモ | uspto-grants-2015_11 |