3,4-Dimethoxyaniline → N2,N4-bis-(3,4-dimethoxyphenyl)-5-nitro-2,4-pyrimidinediamine

HRID 71380

反応式

HRID 71380 の反応式
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[O:21][CH3:22])[NH2:17]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([NH:17][C:2]2[N:7]=[C:6]([NH:17][C:16]3[CH:18]=[CH:19][C:20]([O:21][CH3:22])=[C:14]([O:13][CH3:12])[CH:15]=3)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=2)[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

参加物

3

反応物 2

HCID 227703,4-DimethoxyanilineHCID 5212662,4-Dichloro-5-nitropyrimidine

生成物 1

HCID 22061102N2,N4-bis-(3,4-dimethoxyphenyl)-5-nitro-2,4-pyrimidinediamine

実験手順

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-nitropyrimidine with 3,4-dimethoxyaniline gave N2,N4-bis-(3,4-dimethoxyphenyl)-5-nitro-2,4-pyrimidinediamine. LCMS: ret. time: 28.30 min.; purity: 100%; MS (m/e): 428 (MH+); 1H NMR (CDCl3): δ 10.30 (1H, s), 9.14 (1H, s), 7.52 (1H, s), 7.08 (3H, m), 7.00 (1H, d, J=8.4 Hz), 6.84 (1H, d, J=8.4 Hz), 6.76 (1H, d, J=8.4 Hz), 3.90 (3H, s), 3.87 (3H, s), 3.68 (3H, s), 3.60 (3H, s).

後処理

  1. customIn like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

出典と根拠

ORDレコード
ord-f45076b5efc4470386cde8b1b4157667
出典データセット
uspto-grants-2014_09
特許番号
US08822685B2

関連ノート

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