2,4-Dichloro-5-fluoropyrimidine → N2,N4-bis-(3-isopropylphenyl)-5-fluoro-2,4-pyrimidinediamine

HRID 71388

反応式

HRID 71388 の反応式
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[CH:10]([C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16])([CH3:12])[CH3:11]>>[CH:10]([C:13]1[CH:14]=[C:15]([NH:16][C:2]2[N:7]=[C:6]([NH:16][C:15]3[CH:17]=[CH:18][CH:19]=[C:13]([CH:10]([CH3:12])[CH3:11])[CH:14]=3)[C:5]([F:9])=[CH:4][N:3]=2)[CH:17]=[CH:18][CH:19]=1)([CH3:12])[CH3:11]

参加物

3

反応物 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 4586793-Isopropylaniline

生成物 1

HCID 22060803N2,N4-bis-(3-isopropylphenyl)-5-fluoro-2,4-pyrimidinediamine

実験手順

In like manner to the preparation of N2,N4-bis-(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 3-isopropylaniline were reacted to give N2,N4-bis-(3-isopropylphenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 29.58 min.; Purity: 98%; MS (m/e): 365 (MH+); 1H NMR (DMSO-d6): δ 10.5 (1H, s), 10.34 (1H, s), 8.41 (1H, d, J=5.1 Hz), 7.62 (1H, d, J=8.1 Hz), 7.53 (1H, s), 7.43 (1H, d, J=8.1 Hz), 7.37 (2H, m), 7.29 (1H, t, J=8.1 Hz), 7.19 (1H, d, J=7.8 Hz), 7.08 (1H, d, J=7.8 Hz), 2.88 (2H, m), 1.25 (6H, d, J=7.2 Hz), 1.201 (6H, d, J=7.2 Hz).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-663f4bde64bf45dc912a7ca14d2678aa
出典データセット
uspto-grants-2014_09
特許番号
US08822685B2

関連ノート

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