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4-Cyanophenylboronic acid → (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| 反応物 | (rac)-4-Bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol | HCID 89846267 | — |
| 生成物 | (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile | HCID 71811407 | 79% |
反応手順
In analogy to the procedure described for the preparation of example 1, (rac)-4-bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-3) was reacted with 4-cyanophenylboronic acid to give the title compound as white powder in 79% yield. MS: 355.2 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09187429B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-d5fc4687a2ee40b8b403260ee64fe309 |
| 出典メモ | uspto-grants-2015_11 |