4-Cyanophenylboronic acid → (rac)-N-(4-(4-Cyanophenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide
反応式
Br[C:2]1[C:3]2[CH2:10][CH2:9][CH:8]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])[C:4]=2[CH:5]=[N:6][CH:7]=1.[C:16]([C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1)#[N:17]>>[C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:2]2[C:3]3[CH2:10][CH2:9][CH:8]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])[C:4]=3[CH:5]=[N:6][CH:7]=2)=[CH:20][CH:19]=1)#[N:17]参加物
3
実験手順
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide (intermediate A-4) was reacted with 4-cyanophenylboronic acid to give the title compound as light green powder in 79% yield. MS: 292.1 (M+H+).
出典と根拠
- ORDレコード
- ord-db47630ecd9540de822e92238ba9b3e5
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09187429B2
反応ノート
読み込み中…