p-Aminophenylacetic acid ethyl ester → N2,N4-bis[4-(ethoxycarbonylmethyl)phenyl]-5-trifluoromethyl-2,4-pyrimidinediamine

HRID 71409

反応式

HRID 71409 の反応式
O[C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18](O)[CH:17]=3)[C:12](F)=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.ClC1N=C(Cl)C([C:32]([F:35])([F:34])[F:33])=CN=1.NC1C=CC([CH2:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])=CC=1>>[CH2:47]([O:46][C:44]([CH2:43][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])=[CH:18][CH:17]=3)[C:12]([C:32]([F:33])([F:34])[F:35])=[CH:11][N:10]=2)=[CH:3][CH:2]=1)=[O:45])[CH3:48]

参加物

4

反応物 3

HCID 225219p-Aminophenylacetic acid ethyl esterHCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidineHCID 9904854R-112

生成物 1

HCID 22061076N2,N4-bis[4-(ethoxycarbonylmethyl)phenyl]-5-trifluoromethyl-2,4-pyrimidinediamine

実験手順

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-trifluoromethylpyrimidine and ethyl 4-aminophenylacetate were reacted to yield N2,N4-bis[4-(ethoxycarbonylmethyl)phenyl]-5-trifluoromethyl-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 8.31 (s, 1H), 7.46 (d, 2H, J=9.0 Hz), 7.45 (d, 2H, J=8.7 Hz), 7.30 (d, 2H, J=9.0 Hz), 7.18 (d, 2H, J=8.7 Hz), 7.16 (bs, 1H), 6.82 (bs, 1H), 4.16 (2q, 4H, J=7.8 Hz), 3.64 (s, 2H), 3.57 (s, 2H), 1.27 (t, 3H, J=7.8 Hz), 1.26 (t, 3H, J=7.8 Hz); 19F NMR (CDCl3): −17223; LCMS: ret. time: 28.07 min.; purity: 99%; MS (m/e): 504 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-d95495eea5ef427e9db8bb6bc44bef89
出典データセット
uspto-grants-2014_09
特許番号
US08822685B2

関連ノート

読み込み中…