4-(Trifluoromethyl)phenylboronic acid → (rac)-4-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol
反応式
Br[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH:7]([OH:12])[C:6]=2[CH:5]=[N:4][CH:3]=1.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][C:18]([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH:7]([OH:12])[C:6]=3[CH:5]=[N:4][CH:3]=2)=[CH:17][CH:16]=1参加物
3
実験手順
In analogy to the procedure described for the preparation of example 1 (rac)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-2) was reacted with 4-(trifluoromethyl)phenylboronic acid to give the title compound as white solid in 86% yield. MS: 294.1 (M+H+).
出典と根拠
- ORDレコード
- ord-2e0647af60c348c7806b27948af4a4b5
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09187429B2
反応ノート
読み込み中…