2-Aminopentanenitrile → 3-(3,5-Difluorophenyl)propane-1,2-diamine

HRID 714283ノート

反応式

HRID 714283 の反応式
NC(CCC)C#N.[NH2:8][CH:9]([CH2:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=1)[C:10]([NH2:12])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:20][C:18]1[CH:19]=[C:14]([CH2:13][CH:9]([NH2:8])[CH2:10][NH2:12])[CH:15]=[C:16]([F:21])[CH:17]=1

参加物

4

反応物 3

HCID 101712882-AminopentanenitrileHCID 21226445Aluminium lithium hydrideHCID 582479162-Amino-3-(3,5-difluorophenyl)propanamide

生成物 1

HCID 582477873-(3,5-Difluorophenyl)propane-1,2-diamine収率 75%

実験手順

Following the procedure as described in Preparation 11, making variations as required to replace 2-aminopentanenitrile with 2-amino-3-(3,5-difluorophenyl)-propanamide to react with lithium aluminum hydride, 3-(3,5-difluorophenyl)propane-1,2-diamine was obtained as a colorless solid in 75% yield: The crude product was used for the next step.

後処理

  1. customas described in Preparation 11

出典と根拠

ORDレコード
ord-4609afaddb47449882cfad8094bf2ced
出典データセット
uspto-grants-2015_11
特許番号
US09187426B2

反応ノート

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