Trimethylsilyldiazomethane → Methyl 3-acetylbenzoate

HRID 714457ノート

反応式

HRID 714457 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:13][Si](C=[N+]=[N-])(C)C>C1(C)C=CC=CC=1.CO.C(OCC)C>[C:1]([C:4]1[CH:5]=[C:6]([C:7]([O:9][CH3:13])=[O:8])[CH:10]=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

参加物

6

反応物 2

HCID 167693Trimethylsilyldiazomethane2 回HCID 2203243-Acetylbenzoic acid

生成物 1

HCID 15094405Methyl 3-acetylbenzoate

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒2 回

実験手順

3.95 g (24.06 mmol) of 3-acetylbenzoic acid were initially charged in 100 ml of toluene and 75 ml of methanol. After dropwise addition of 4.12 g (36.09 mmol) of trimethylsilyldiazomethane 2M in diethyl ether at RT, an instant evolution of gas in the reaction solution was observed. Another 0.27 g (2.4 mmol) of trimethylsilyldiazomethane 2M in diethyl ether was added until the reaction solution remained yellow, and the mixture was stirred at RT for 10 min. The reaction solution was evaporated.

後処理

  1. customThe reaction solution was evaporated

出典と根拠

ORDレコード
ord-a4185f0c5e674338ac906d2a2b68008f
出典データセット
uspto-grants-2015_11
特許番号
US09187428B2

反応ノート

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