Hydrochloric Acid → HCID 66633775、化合物
反応式
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[CH:11]=[C:12]([C:16]([NH:18][CH2:19][CH2:20][NH:21]C(=O)OC(C)(C)C)=[O:17])[CH:13]=[CH:14][CH:15]=2)[C:5]([C:29]#[N:30])=[C:4]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:3]=1[C:37]#[N:38].[ClH:39]>O1CCOCC1>[ClH:39].[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[CH:11]=[C:12]([C:16]([NH:18][CH2:19][CH2:20][NH2:21])=[O:17])[CH:13]=[CH:14][CH:15]=2)[C:5]([C:29]#[N:30])=[C:4]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:3]=1[C:37]#[N:38]参加物
4
実験手順
79 mg (0.15 mmol) of tert-butyl (2-{[(3-{[(6-amino-3,5-dicyano-4-phenylpyridin-2-yl)sulfanyl]-methyl}phenyl)carbonyl]amino}ethyl)carbamate Example 57A were initially charged in 1 ml of dioxane. After addition of 21.6 mg (0.6 mmol) of 4 N hydrochloric acid in dioxane, the mixture was stirred at RT overnight. The reaction mixture was evaporated. The residue was purified by preparative HPLC (Chromasil, water/acetonitrile).