Sodium Methoxide → HCID 178497762、化合物

HRID 714681ノート

反応式

HRID 714681 の反応式
Br.[F:2][C:3]([F:15])([F:14])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11](=[NH:13])[NH2:12].C[O-].[Na+].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:30]([CH2:31][C:32]3[CH:33]=[C:34]([C:38]([O:40][CH3:41])=[O:39])[CH:35]=[CH:36][CH:37]=3)[C:29](=[O:42])[N:28]([CH2:43][C:44]([NH:46]N)=O)[N:27]=2)=[CH:22][CH:21]=1>CO>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:30]([CH2:31][C:32]3[CH:33]=[C:34]([C:38]([O:40][CH3:41])=[O:39])[CH:35]=[CH:36][CH:37]=3)[C:29](=[O:42])[N:28]([CH2:43][C:44]3[NH:12][C:11]([CH2:10][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[C:3]([F:14])([F:15])[F:2])=[N:13][N:46]=3)[N:27]=2)=[CH:22][CH:21]=1

参加物

5

反応物 3

HCID 10942334Sodium MethoxideHCID 673965422-[2-(Trifluoromethyl)phenyl]ethaneimidamide hydrobromideHCID 69940030Methyl 3-{[3-(4-chlorophenyl)-1-(2-hydrazino-2-oxoethyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]methyl}benzenecarboxylate

生成物 1

HCID 178497762HCID 178497762、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

77 mg (0.27 mmol) of 2-[2-(trifluoromethyl)phenyl]ethaneimidamide hydrobromide were dissolved in 1 ml of dry methanol, 74 μl (0.27 mmol) of a 25% strength methanolic sodium methoxide solution were added and the mixture was stirred for 30 min 75 mg (0.18 mmol) of the compound from Example 16A were then added, and the mixture was stirred initially at RT for 16 h and then under reflux for 5 h. The mixture was then directly purified chromatographically [Method 19]. This gave 67 mg (64% of theory) of the target compound as a colorless foam.

後処理

  1. additionwere then added
  2. temperatureunder reflux for 5 h
  3. customThe mixture was then directly purified chromatographically [Method 19]

出典と根拠

ORDレコード
ord-28b9a73569e54cbaaf95393077f47b5f
出典データセット
uspto-grants-2015_11
特許番号
US09187466B2

反応ノート

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