化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 2-(Methylthio)-1H-pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Thiouracil | HCID 1269845 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Methyl iodide | HCID 6328 | — |
| 生成物 | 2-(Methylthio)-1H-pyrimidin-4-one | HCID 79823 | — |
反応手順
To 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (21 g) was added dropwise a solution of sodium hydroxide (13 g) in water (120 mL), iodomethane (11.5 mL) was added thereto, and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (9.5 mL), and the resulting solid was collected by filtration. The obtained solid was washed with cold water to give the title compound (24 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09187453B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-34b66474704041fea99a3a36c45d8f29 |
| 出典メモ | uspto-grants-2015_11 |