N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide → N-(2-(4-amino-1H-pyrazol-1-yl)ethyl)methanesulfonamide

HRID 714904ノート

反応式

HRID 714904 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=1

参加物

4

反応物 1

HCID 117840477N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide

生成物 1

HCID 73439022N-(2-(4-amino-1H-pyrazol-1-yl)ethyl)methanesulfonamide収率 112.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a solution of N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide (880 mg) obtained in Step A of Example 349 in ethanol (30 mL) was added 10% palladium-carbon (200 mg), and the mixture was stirred at room temperature for 3 hr under hydrogen atmosphere (at normal pressures). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (860 mg).

後処理

  1. customThe palladium carbon was removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-844c77046182491c837eb0f12d8ea02a
出典データセット
uspto-grants-2015_11
特許番号
US09187453B2

反応ノート

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