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4-Isopropylaniline → 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Isopropylaniline | HCID 7464 | — |
| 反応物 | 2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine | HCID 22060451 | — |
| 生成物 | 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine | HCID 22060781 | — |
反応手順
In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 4-isopropylaniline gave 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 23.08 min.; purity: 99%; MS (m/e): 439 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822685B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c6e3beb385354e8c9c7fdd0fec56f57d |
| 出典メモ | uspto-grants-2014_09 |